Including known covariates can reduce power to detect genetic effects in case-control studies
Including known covariates can reduce power to detect genetic effects in case-control studies
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Peter Donnelly and colleagues report an analysis considering the inclusion of non-confounding covariates within genome-wide association studies and provide software that can be used to assess the impact on power within a particular study. They find that, when the disease prevalence is low, including known covariates, such as sex or established gene...
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Including known covariates can reduce power to detect genetic effects in case-control studies
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TN_cdi_proquest_miscellaneous_1034820621
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1034820621
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.2346
