Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons
Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Here the authors show that the binding of amyloid-β (Aβ) oligomers to cellular prion protein (PrPc) activates Fyn kinase. Aβ stimulation of PrPc/Fyn signaling drives phosphorylation of the NR2B subunit of NMDA receptors, with a subsequent loss of receptor surface expression and dendritic spines.
Amyloid-beta (Aβ) oligomers are thought to trigger...
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Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons
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TN_cdi_proquest_miscellaneous_1093470319
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1093470319
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.3178
