Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Excess free fatty acids (FFAs) are known to induce insulin resistance, and a role for TLR4 has been implicated in this process. But FFAs are believed to be incapable of binding TLR4 directly. In a new study, Samir Bhattacharya and colleagues show that fetuin-A acts as an intermediary in this process by bindings FFAs and presenting them to TLR4. The...
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Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
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TN_cdi_proquest_miscellaneous_1221142160
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1221142160
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2851
