A dual function of the furanocoumarin chalepensin in inhibiting Cyp2a and inducing Cyp2b in mice: th...
A dual function of the furanocoumarin chalepensin in inhibiting Cyp2a and inducing Cyp2b in mice: the protein stabilization and receptor-mediated activation
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Berlin/Heidelberg: Springer-Verlag
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English
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Berlin/Heidelberg: Springer-Verlag
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Chalepensin, a furanocoumarin, is present in several medicinal Rutaceae plants and causes a mechanism-based inhibition of human and mouse cytochrome P450 (P450, CYP) 2A in vitro. To address the in vivo effect, we investigated the effects of chalepensin on multiple hepatic P450 enzymes in C57BL/6JNarl mice. Oral administration of 10 mg/kg chalepensi...
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Full title
A dual function of the furanocoumarin chalepensin in inhibiting Cyp2a and inducing Cyp2b in mice: the protein stabilization and receptor-mediated activation
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TN_cdi_proquest_miscellaneous_1257764409
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1257764409
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ISSN
0340-5761
E-ISSN
1432-0738
DOI
10.1007/s00204-012-0902-7
