Dclk1 distinguishes between tumor and normal stem cells in the intestine
Dclk1 distinguishes between tumor and normal stem cells in the intestine
About this item
Full title
Author / Creator
Nakanishi, Yuki , Seno, Hiroshi , Fukuoka, Ayumi , Ueo, Taro , Yamaga, Yuichi , Maruno, Takahisa , Nakanishi, Naoko , Kanda, Keitaro , Komekado, Hideyuki , Kawada, Mayumi , Isomura, Akihiro , Kawada, Kenji , Sakai, Yoshiharu , Yanagita, Motoko , Kageyama, Ryoichiro , Kawaguchi, Yoshiya , Taketo, Makoto M , Yonehara, Shin and Chiba, Tsutomu
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Hiroshi Seno and colleagues report that Dclk1 selectively marks intestinal tumor stem cells. They further show that specific ablation of these cells in a mouse tumor model results in a pronounced regression of polyps without apparent damage to normal intestinal tissue.
There is great interest in tumor stem cells (TSCs) as potential therapeutic t...
Alternative Titles
Full title
Dclk1 distinguishes between tumor and normal stem cells in the intestine
Authors, Artists and Contributors
Author / Creator
Seno, Hiroshi
Fukuoka, Ayumi
Ueo, Taro
Yamaga, Yuichi
Maruno, Takahisa
Nakanishi, Naoko
Kanda, Keitaro
Komekado, Hideyuki
Kawada, Mayumi
Isomura, Akihiro
Kawada, Kenji
Sakai, Yoshiharu
Yanagita, Motoko
Kageyama, Ryoichiro
Kawaguchi, Yoshiya
Taketo, Makoto M
Yonehara, Shin
Chiba, Tsutomu
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1291601444
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1291601444
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.2481
