Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibi...
Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Development of novel influenza neuraminidase inhibitors is critical for preparedness against influenza outbreaks. Knowledge of the neuraminidase enzymatic mechanism and transition-state analogue, 2-deoxy-2,3-didehydro-
N
-acetylneuraminic acid, contributed to the development of the first generation anti-neuraminidase drugs, zanamivir and osel...
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Full title
Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors
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TN_cdi_proquest_miscellaneous_1291617374
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1291617374
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms2487
