Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrange...
Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements
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Publisher
New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Large-scale sequencing has recently revealed the presence of highly complex, localized chromosomal rearrangements in cancer genomes. The authors discuss the evidence that such rearrangements can occur through at least two mechanisms: chromosomal shattering (chromothripsis) and template switching initiated by local defective DNA replication (chromoa...
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Full title
Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements
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TN_cdi_proquest_miscellaneous_1315624518
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1315624518
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2988
