The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm
The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm
About this item
Full title
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
An X-ray crystal structure of sarcoplasmic reticulum Ca
2+
-ATPase (SERCA) in the presence of sarcolipin, a SERCA regulator, is presented; the structure shows that sarcolipin traps SERCA in a previously unidentified ‘open’ state in which its high-affinity Ca
2+
-binding sites are unoccupied, but accessible from the cytoplasm.
How cal...
Alternative Titles
Full title
The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm
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Record Identifier
TN_cdi_proquest_miscellaneous_1317407746
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1317407746
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature11900
