Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
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Author / Creator
Kim, Hong Joo , Kim, Nam Chul , Wang, Yong-Dong , Scarborough, Emily A. , Moore, Jennifer , Diaz, Zamia , MacLea, Kyle S. , Freibaum, Brian , Li, Songqing , Molliex, Amandine , Kanagaraj, Anderson P. , Carter, Robert , Boylan, Kevin B. , Wojtas, Aleksandra M. , Rademakers, Rosa , Pinkus, Jack L. , Greenberg, Steven A. , Trojanowski, John Q. , Traynor, Bryan J. , Smith, Bradley N. , Topp, Simon , Gkazi, Athina-Soragia , Miller, Jack , Shaw, Christopher E. , Kottlors, Michael , Kirschner, Janbernd , Pestronk, Alan , Li, Yun R. , Ford, Alice Flynn , Gitler, Aaron D. , Benatar, Michael , King, Oliver D. , Kimonis, Virginia E. , Ross, Eric D. , Weihl, Conrad C. , Shorter, James and Taylor, J. Paul
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London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Algorithms designed to identify canonical yeast prions predict that around 250 human proteins, including several RNA-binding proteins associated with neurodegenerative disease, harbour a distinctive prion-like domain (PrLD) enriched in uncharged polar amino acids and glycine. PrLDs in RNA-binding proteins are essential for the assembly of ribonucle...
Alternative Titles
Full title
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
Authors, Artists and Contributors
Author / Creator
Kim, Nam Chul
Wang, Yong-Dong
Scarborough, Emily A.
Moore, Jennifer
Diaz, Zamia
MacLea, Kyle S.
Freibaum, Brian
Li, Songqing
Molliex, Amandine
Kanagaraj, Anderson P.
Carter, Robert
Boylan, Kevin B.
Wojtas, Aleksandra M.
Rademakers, Rosa
Pinkus, Jack L.
Greenberg, Steven A.
Trojanowski, John Q.
Traynor, Bryan J.
Smith, Bradley N.
Topp, Simon
Gkazi, Athina-Soragia
Miller, Jack
Shaw, Christopher E.
Kottlors, Michael
Kirschner, Janbernd
Pestronk, Alan
Li, Yun R.
Ford, Alice Flynn
Gitler, Aaron D.
Benatar, Michael
King, Oliver D.
Kimonis, Virginia E.
Ross, Eric D.
Weihl, Conrad C.
Shorter, James
Taylor, J. Paul
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1321793017
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1321793017
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/nature11922
