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Cellular Uptake Mechanisms of Novel Anionic siRNA Lipoplexes

Cellular Uptake Mechanisms of Novel Anionic siRNA Lipoplexes

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1323815998

Cellular Uptake Mechanisms of Novel Anionic siRNA Lipoplexes

About this item

Full title

Cellular Uptake Mechanisms of Novel Anionic siRNA Lipoplexes

Publisher

Boston: Springer US

Journal title

Pharmaceutical research, 2013-04, Vol.30 (4), p.1161-1175

Language

English

Formats

Publication information

Publisher

Boston: Springer US

More information

Scope and Contents

Contents

ABSTRACT
Purpose
To investigate cellular uptake pathways of novel anionic siRNA-lipoplexes as a function of formulation composition.
Methods
Anionic formulations with anionic lipid/Ca
2+
/siRNA ratio of 1.3/2.5/1 (AF1) and 1.3/0.3/1 (AF2) were utilized. Uptake mechanisms were investigated using uptake inhibition and co-localizatio...

Alternative Titles

Full title

Cellular Uptake Mechanisms of Novel Anionic siRNA Lipoplexes

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1323815998

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1323815998

Other Identifiers

ISSN

0724-8741

E-ISSN

1573-904X

DOI

10.1007/s11095-012-0952-9

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