Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity
Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Human soluble interleukin-7 receptor (sIL7R)α circulates in high molar excess compared with IL-7, but its biology remains unclear. We demonstrate that sIL7Rα has moderate affinity for IL-7 but does not bind thymic stromal lymphopoietin. Functionally, sIL7Rα competes with cell-associated IL-7 receptor to diminish excessive IL-7 consumption and, thus...
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Full title
Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity
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TN_cdi_proquest_miscellaneous_1349704987
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1349704987
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1222303110
