Nicotinamide mononucleotide adenylyltransferase2 overexpression enhances colorectal cancer cell-kill...
Nicotinamide mononucleotide adenylyltransferase2 overexpression enhances colorectal cancer cell-kill by Tiazofurin
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Full title
Author / Creator
Kusumanchi, P , Zhang, Y , Jani, M B , Jayaram, N H , Khan, R A , Tang, Y , Antony, A C and Jayaram, H N
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Colorectal cancer cells exhibit limited cytotoxicity towards Tiazofurin, a pro-drug metabolized by cytosolic nicotinamide mononucleotide adenylyltransferase2 (NMNAT2) to thiazole-4-carboxamide adenine dinucleotide, a potent inhibitor of inosine 5′-monophosphate dehydrogenase required for cellular guanylate synthesis. We tested the hypothesis that c...
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Full title
Nicotinamide mononucleotide adenylyltransferase2 overexpression enhances colorectal cancer cell-kill by Tiazofurin
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Author / Creator
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Record Identifier
TN_cdi_proquest_miscellaneous_1419358559
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1419358559
Other Identifiers
ISSN
0929-1903
E-ISSN
1476-5500
DOI
10.1038/cgt.2013.33
