β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease
β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
The mechanism whereby activation of G protein–coupled receptors (GPCRs) increase the production of amyloid-β (Aβ) peptide remains unclear. Here Bart De Strooper and colleagues show that the GPCR adaptor protein β-arrestin 2 promotes Aβ production by associating with APH-1A and increasing γ-secretase activity. Overexpression of β-arrestin 2 increase...
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Full title
β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease
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TN_cdi_proquest_miscellaneous_1419370945
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1419370945
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3023
