The spindle assembly checkpoint works like a rheostat rather than a toggle switch
The spindle assembly checkpoint works like a rheostat rather than a toggle switch
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The spindle assembly checkpoint (SAC) keeps the APC/C ubiquitin ligase inactive until all chromosomes are attached to the spindle. Pines and colleagues tagged endogenous cyclin A with a fluorescent protein by gene targeting and used cyclin A degradation as an assay for SAC activity. They found that the SAC does not show an all-or-nothing response—i...
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Full title
The spindle assembly checkpoint works like a rheostat rather than a toggle switch
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TN_cdi_proquest_miscellaneous_1449275350
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1449275350
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb2855
