Posttranslational modification of HLA-DQ binding islet autoantigens in type 1 diabetes
Posttranslational modification of HLA-DQ binding islet autoantigens in type 1 diabetes
About this item
Full title
Author / Creator
Publisher
United States: American Diabetes Association
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Diabetes Association
Subjects
More information
Scope and Contents
Contents
Posttranslational modification (PTM) of islet autoantigens can cause lack of central tolerance in type 1 diabetes (T1D). Tissue transglutaminase (tTG), involved in PTM of gluten antigens in celiac disease, creates negatively charged peptides favored by T1D-predisposing HLA-DQ molecules, offering an attractive candidate modifying islet autoantigens...
Alternative Titles
Full title
Posttranslational modification of HLA-DQ binding islet autoantigens in type 1 diabetes
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1490778376
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1490778376
Other Identifiers
ISSN
0012-1797
E-ISSN
1939-327X
DOI
10.2337/db12-1214
