Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis
Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis
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Publisher
United States: American Association for the Advancement of Science
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Language
English
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Publisher
United States: American Association for the Advancement of Science
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Contents
Receptor-interacting protein kinase 1 (RIPK1) and RIPK3 trigger pro-inflammatory cell death termed "necroptosis." Studies with RIPK3-deficient mice or the RIPK1 inhibitor necrostatin-1 suggest that necroptosis exacerbates pathology in many disease models. We engineered mice expressing catalytically inactive RIPK3 D161N or RIPK1 D138N to determine t...
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Full title
Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis
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TN_cdi_proquest_miscellaneous_1509415176
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1509415176
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1249361
