MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes
MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Type 1 diabetes (T1D) and type 2 diabetes (T2D) are both hallmarked by loss of insulin-producing pancreatic beta cells. Kathrin Maedler and her colleagues now show that the kinase MST1 is upregulated by diabetic conditions in beta cells, resulting in their dysfunction and their apoptosis. They also show that genetic knockout of the gene encoding Ms...
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Full title
MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes
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TN_cdi_proquest_miscellaneous_1514437146
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1514437146
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3482
