Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics
Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics
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United States
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English
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United States
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Activation of the small guanosine triphosphatase H-Ras by the exchange factor Son of Sevenless (SOS) is an important hub for signal transduction. Multiple layers of regulation, through protein and membrane interactions, govern activity of SOS. We characterized the specific activity of individual SOS molecules catalyzing nucleotide exchange in H-Ras...
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Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics
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TN_cdi_proquest_miscellaneous_1543281049
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1543281049
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E-ISSN
1095-9203
DOI
10.1126/science.1250373
