Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-cont...
Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial
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for the AL-108-231 Investigators , AL-108-231 Investigators , Boxer, Adam L, Dr , Lang, Anthony E, Prof , Grossman, Murray, Prof , Knopman, David S, Prof , Miller, Bruce L, Prof , Schneider, Lon S, Prof , Doody, Rachelle S, Prof , Lees, Andrew, Prof , Golbe, Lawrence I, Prof , Williams, David R, MD , Corvol, Jean-Cristophe, MD , Ludolph, Albert, Prof , Burn, David, Prof , Lorenzl, Stefan, Prof , Litvan, Irene, Prof , Roberson, Erik D, MD , Höglinger, Günter U, Prof , Koestler, Mary, PhD , Jack, Clifford R, Prof , Van Deerlin, Viviana, MD , Randolph, Christopher, Prof , Lobach, Iryna V, PhD , Heuer, Hilary W, PhD , Gozes, Illana, Prof , Parker, Lesley, BSc , Whitaker, Steve, MD , Hirman, Joe, PhD , Stewart, Alistair J, PhD , Gold, Michael, MD and Morimoto, Bruce H, PhD
Publisher
England: Elsevier Ltd
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English
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Publisher
England: Elsevier Ltd
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Summary Background In preclinical studies, davunetide promoted microtubule stability and reduced tau phosphorylation. Because progressive supranuclear palsy (PSP) is linked to tau pathology, davunetide could be a treatment for PSP. We assessed the safety and efficacy of davunetide in patients with PSP. Methods In a double-blind, parallel group, pha...
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Full title
Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial
Authors, Artists and Contributors
Author / Creator
AL-108-231 Investigators
Boxer, Adam L, Dr
Lang, Anthony E, Prof
Grossman, Murray, Prof
Knopman, David S, Prof
Miller, Bruce L, Prof
Schneider, Lon S, Prof
Doody, Rachelle S, Prof
Lees, Andrew, Prof
Golbe, Lawrence I, Prof
Williams, David R, MD
Corvol, Jean-Cristophe, MD
Ludolph, Albert, Prof
Burn, David, Prof
Lorenzl, Stefan, Prof
Litvan, Irene, Prof
Roberson, Erik D, MD
Höglinger, Günter U, Prof
Koestler, Mary, PhD
Jack, Clifford R, Prof
Van Deerlin, Viviana, MD
Randolph, Christopher, Prof
Lobach, Iryna V, PhD
Heuer, Hilary W, PhD
Gozes, Illana, Prof
Parker, Lesley, BSc
Whitaker, Steve, MD
Hirman, Joe, PhD
Stewart, Alistair J, PhD
Gold, Michael, MD
Morimoto, Bruce H, PhD
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Record Identifier
TN_cdi_proquest_miscellaneous_1544017031
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1544017031
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ISSN
1474-4422
E-ISSN
1474-4465
DOI
10.1016/S1474-4422(14)70088-2
