Alzheimer disease therapy—moving from amyloid-β to tau
Alzheimer disease therapy—moving from amyloid-β to tau
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Notable failures of amyloid-β-targeted therapies in late-stage clinical trials for Alzheimer disease (AD) suggest the need for a reassessment of the amyloid cascade hypothesis of AD pathology. Here, Giacobini and Gold discuss the limitations of focusing on amyloid-β, and suggest a shift towards tau-directed therapy. They outline the rationale for s...
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Full title
Alzheimer disease therapy—moving from amyloid-β to tau
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TN_cdi_proquest_miscellaneous_1566841950
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1566841950
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ISSN
1759-4758
E-ISSN
1759-4766
DOI
10.1038/nrneurol.2013.223