RAS–MAPK–MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1
RAS–MAPK–MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1
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Author / Creator
Park, Jeehye , Al-Ramahi, Ismael , Tan, Qiumin , Mollema, Nissa , Diaz-Garcia, Javier R. , Gallego-Flores, Tatiana , Lu, Hsiang-Chih , Lagalwar, Sarita , Duvick, Lisa , Kang, Hyojin , Lee, Yoontae , Jafar-Nejad, Paymaan , Sayegh, Layal S. , Richman, Ronald , Liu, Xiuyun , Gao, Yan , Shaw, Chad A. , Arthur, J. Simon C. , Orr, Harry T. , Westbrook, Thomas F. , Botas, Juan and Zoghbi, Huda Y.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Many neurodegenerative disorders, such as Alzheimer’s, Parkinson’s and polyglutamine diseases, share a common pathogenic mechanism: the abnormal accumulation of disease-causing proteins, due to either the mutant protein’s resistance to degradation or overexpression of the wild-type protein. We have developed a strategy to identify therapeutic entry...
Alternative Titles
Full title
RAS–MAPK–MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1
Authors, Artists and Contributors
Author / Creator
Al-Ramahi, Ismael
Tan, Qiumin
Mollema, Nissa
Diaz-Garcia, Javier R.
Gallego-Flores, Tatiana
Lu, Hsiang-Chih
Lagalwar, Sarita
Duvick, Lisa
Kang, Hyojin
Lee, Yoontae
Jafar-Nejad, Paymaan
Sayegh, Layal S.
Richman, Ronald
Liu, Xiuyun
Gao, Yan
Shaw, Chad A.
Arthur, J. Simon C.
Orr, Harry T.
Westbrook, Thomas F.
Botas, Juan
Zoghbi, Huda Y.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1566842031
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1566842031
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature12204
