Crucial role of nonspecific interactions in amyloid nucleation
Crucial role of nonspecific interactions in amyloid nucleation
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Significance The assembly of normally soluble proteins into large fibrils, known as amyloid aggregation, is associated with a range of pathologies. Prefibrillar protein oligomers but not the grown fibers are believed to be the main toxic agents. It is unresolved if these oligomers are necessary for fibril assembly or just a dangerous byproduct. We...
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Full title
Crucial role of nonspecific interactions in amyloid nucleation
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TN_cdi_proquest_miscellaneous_1637995403
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1637995403
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1410159111
