Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
In studies in mammalian cells, polymerase theta (Polθ, also known as POLQ) is identified as the polymerase responsible for non-homologous end joining DNA repair; this DNA repair pathway acts in many tumours when homologous recombination is inactivated and the identification of the polymerase responsible may aid the development of new therapeutic ap...
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Full title
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
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TN_cdi_proquest_miscellaneous_1655257846
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1655257846
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature14184
