EGFR gene gain and PTEN protein expression are favorable prognostic factors in patients with KRAS wi...
EGFR gene gain and PTEN protein expression are favorable prognostic factors in patients with KRAS wild-type metastatic colorectal cancer treated with cetuximab
About this item
Full title
Author / Creator
Razis, Evangelia , Pentheroudakis, George , Rigakos, George , Bobos, Mattheos , Kouvatseas, George , Tzaida, Olympia , Makatsoris, Thomas , Papakostas, Pavlos , Bai, Maria , Goussia, Anna , Samantas, Epaminontas , Papamichael, Demetrios , Romanidou, Ourania , Efstratiou, Ioannis , Tsolaki, Eleftheria , Psyrri, Amanda , De Roock, Wendy , Bafaloukos, Dimitrios , Klouvas, George , Tejpar, Sabine , Kalogeras, Konstantine T. , Pectasides, Dimitrios and Fountzilas, George
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Introduction
Cetuximab is a monoclonal epidermal growth factor receptor (EGFR)-targeting antibody, used in the treatment of colon cancer.
KRAS
mutation status is strongly predictive of cetuximab efficacy, but more predictive factors are needed for better patient selection. PTEN is a downstream inhibitor of the EGFR pathway and has been eva...
Alternative Titles
Full title
EGFR gene gain and PTEN protein expression are favorable prognostic factors in patients with KRAS wild-type metastatic colorectal cancer treated with cetuximab
Authors, Artists and Contributors
Author / Creator
Pentheroudakis, George
Rigakos, George
Bobos, Mattheos
Kouvatseas, George
Tzaida, Olympia
Makatsoris, Thomas
Papakostas, Pavlos
Bai, Maria
Goussia, Anna
Samantas, Epaminontas
Papamichael, Demetrios
Romanidou, Ourania
Efstratiou, Ioannis
Tsolaki, Eleftheria
Psyrri, Amanda
De Roock, Wendy
Bafaloukos, Dimitrios
Klouvas, George
Tejpar, Sabine
Kalogeras, Konstantine T.
Pectasides, Dimitrios
Fountzilas, George
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1660406062
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1660406062
Other Identifiers
ISSN
0171-5216
E-ISSN
1432-1335
DOI
10.1007/s00432-014-1626-2
