Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissue...
Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption
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Author / Creator
Rothenberger, Meghan K. , Keele, Brandon F. , Wietgrefe, Stephen W. , Fletcher, Courtney V. , Beilman, Gregory J. , Chipman, Jeffrey G. , Khoruts, Alexander , Estes, Jacob D. , Anderson, Jodi , Callisto, Samuel P. , Schmidt, Thomas E. , Thorkelson, Ann , Reilly, Cavan , Perkey, Katherine , Reimann, Thomas G. , Utay, Netanya S. , Makamdop, Krystelle Nganou , Stevenson, Mario , Douek, Daniel C. , Haase, Ashley T. and Schacker, Timothy W.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Significance Antiretroviral therapy (ART) effectively suppresses HIV replication; however, treatment cannot be stopped, because latently infected CD4+ T cells will rekindle infection. As one estimate of the size of the pool of latently infected cells that must be purged for cure, we asked whether recrudescent infection is the result of reactivation...
Alternative Titles
Full title
Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption
Authors, Artists and Contributors
Author / Creator
Keele, Brandon F.
Wietgrefe, Stephen W.
Fletcher, Courtney V.
Beilman, Gregory J.
Chipman, Jeffrey G.
Khoruts, Alexander
Estes, Jacob D.
Anderson, Jodi
Callisto, Samuel P.
Schmidt, Thomas E.
Thorkelson, Ann
Reilly, Cavan
Perkey, Katherine
Reimann, Thomas G.
Utay, Netanya S.
Makamdop, Krystelle Nganou
Stevenson, Mario
Douek, Daniel C.
Haase, Ashley T.
Schacker, Timothy W.
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1662636413
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1662636413
Other Identifiers
ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.1414926112
