Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease
Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease
About this item
Full title
Author / Creator
Monteleone, Giovanni , Neurath, Markus F , Ardizzone, Sandro , Di Sabatino, Antonio , Fantini, Massimo C , Castiglione, Fabiana , Scribano, Maria L , Armuzzi, Alessandro , Caprioli, Flavio , Sturniolo, Giacomo C , Rogai, Francesca , Vecchi, Maurizio , Atreya, Raja , Bossa, Fabrizio , Onali, Sara , Fichera, Maria , Corazza, Gino R , Biancone, Livia , Savarino, Vincenzo , Pica, Roberta , Orlando, Ambrogio and Pallone, Francesco
Publisher
United States: Massachusetts Medical Society
Journal title
Language
English
Formats
Publication information
Publisher
United States: Massachusetts Medical Society
Subjects
More information
Scope and Contents
Contents
The chronic inflammation of Crohn's disease is caused, at least in part, by repression of TGF-β1 signaling, which is caused by high levels of SMAD7. This trial shows that mongersen, an antisense inhibitor of
SMAD7
mRNA, induces disease remission in some persons.
Crohn’s disease is a chronic inflammatory illness that primarily affects the t...
Alternative Titles
Full title
Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease
Authors, Artists and Contributors
Author / Creator
Neurath, Markus F
Ardizzone, Sandro
Di Sabatino, Antonio
Fantini, Massimo C
Castiglione, Fabiana
Scribano, Maria L
Armuzzi, Alessandro
Caprioli, Flavio
Sturniolo, Giacomo C
Rogai, Francesca
Vecchi, Maurizio
Atreya, Raja
Bossa, Fabrizio
Onali, Sara
Fichera, Maria
Corazza, Gino R
Biancone, Livia
Savarino, Vincenzo
Pica, Roberta
Orlando, Ambrogio
Pallone, Francesco
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1665119840
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1665119840
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa1407250
