Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclero...
Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Rheb is a small GTP-binding protein and its GTPase activity is activated by the complex of Tsc1 and Tsc2 whose mutations cause tuberous sclerosis complex (TSC). We previously reported that cultured TSC neurons showed impaired spine synapse morphogenesis in an mTORC1-independent manner. Here we show that the PDZ protein syntenin preferentially binds...
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Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex
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TN_cdi_proquest_miscellaneous_1674203410
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1674203410
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2041-1723
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2041-1723
DOI
10.1038/ncomms7842
