Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity
Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Insulin-like growth factors (IGFs) induce proliferation of various cell types and play important roles in somatic growth and cancer development. Phosphorylation of insulin receptor substrate (IRS)-1/2 by IGF-I receptor tyrosine kinase is essential for IGF action. Here we identify Nedd4 as an IRS-2 ubiquitin ligase. Nedd4 monoubiquitinates IRS-2, wh...
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Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity
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TN_cdi_proquest_miscellaneous_1674209261
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1674209261
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms7780
