Notch is a direct negative regulator of the DNA-damage response
Notch is a direct negative regulator of the DNA-damage response
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Assays in both
C. elegans
and human cells show that Notch interacts with ATM kinase to inhibit the DNA-damage response and that Notch activity is inversely correlated with ATM activation in breast cancer cells.
The DNA-damage response (DDR) ensures genome stability and proper inheritance of genetic information, both of which are essential...
Alternative Titles
Full title
Notch is a direct negative regulator of the DNA-damage response
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TN_cdi_proquest_miscellaneous_1687674273
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1687674273
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.3013
