The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
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Author / Creator
Youm, Yun-Hee , Nguyen, Kim Y , Grant, Ryan W , Goldberg, Emily L , Bodogai, Monica , Kim, Dongin , D'Agostino, Dominic , Planavsky, Noah , Lupfer, Christopher , Kanneganti, Thirumala D , Kang, Seokwon , Horvath, Tamas L , Fahmy, Tarek M , Crawford, Peter A , Biragyn, Arya , Alnemri, Emad and Dixit, Vishwa Deep
Publisher
New York: Nature Publishing Group US
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English
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Publisher
New York: Nature Publishing Group US
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Contents
Ketone bodies are elevated in response to fasting, a low-carbohydrate ketogenic diet or high-intensity exercise. Vishwa Deep Dixit and colleagues report that one metabolite, β-hydroxybutyrate, inhibits the NLRP3 inflammasome.
In vivo
, β-hydroxybutyrate is anti-inflammatory and suppresses NLRP3-mediated inflammatory disease.
The ketone bod...
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Full title
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
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TN_cdi_proquest_miscellaneous_1694968363
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1694968363
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3804
