Structural and Functional Characterization of a Novel alpha -Conotoxin Mr1.7 from Conus marmoreus Ta...
Structural and Functional Characterization of a Novel alpha -Conotoxin Mr1.7 from Conus marmoreus Targeting Neuronal nAChR alpha 3 beta 2, alpha 9 alpha 10 and alpha 6/ alpha 3 beta 2 beta 3 Subtypes
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Wang, Shuo , Zhao, Cong , Liu, Zhuguo , Wang, Xuesong , Liu, Na , Du, Weihong and Dai, Qiuyun
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English
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In the present study, we synthesized and, structurally and functionally characterized a novel alpha 4/7-conotoxin Mr1.7 (PECCTHPACHVSHPELC-NH2), which was previously identified by cDNA libraries from Conus marmoreus in our lab. The NMR solution structure showed that Mr1.7 contained a 310-helix from residues Pro7 to His10 and a type I beta -turn fro...
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Full title
Structural and Functional Characterization of a Novel alpha -Conotoxin Mr1.7 from Conus marmoreus Targeting Neuronal nAChR alpha 3 beta 2, alpha 9 alpha 10 and alpha 6/ alpha 3 beta 2 beta 3 Subtypes
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TN_cdi_proquest_miscellaneous_1701492777
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1701492777
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E-ISSN
1660-3397
DOI
10.3390/md13063259
