Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma
Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma
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Author / Creator
Kikuchi, S , Suzuki, R , Ohguchi, H , Yoshida, Y , Lu, D , Cottini, F , Jakubikova, J , Bianchi, G , Harada, T , Gorgun, G , Tai, Y-T , Richardson, P G , Hideshima, T and Anderson, K C
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Histone deacetylase (HDAC) inhibitors have been extensively investigated as therapeutic agents in cancer. However, the biological role of class IIa HDACs (HDAC4, 5, 7 and 9) in cancer cells, including multiple myeloma (MM), remains unclear. Recent studies show HDAC4 interacts with activating transcription factor 4 (ATF4) and inhibits activation of...
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Full title
Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma
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TN_cdi_proquest_miscellaneous_1722169614
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1722169614
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ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/leu.2015.83
