Dopamine covalently modifies and functionally inactivates parkin
Dopamine covalently modifies and functionally inactivates parkin
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Inherited mutations in
PARK2
, the gene encoding parkin, cause selective degeneration of catecholaminergic neurons in the substantia nigra and locus coeruleus of the brainstem, resulting in early-onset parkinsonism. But the role of parkin in common, sporadic forms of Parkinson disease remains unclear. Here we report that the neurotransmitter...
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Full title
Dopamine covalently modifies and functionally inactivates parkin
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TN_cdi_proquest_miscellaneous_17242008
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_17242008
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm1314
