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RAF inhibitors that evade paradoxical MAPK pathway activation

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RAF inhibitors that evade paradoxical MAPK pathway activation

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1727436298

RAF inhibitors that evade paradoxical MAPK pathway activation

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Publication information

Publisher

London: Nature Publishing Group UK

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Contents

Next-generation RAF inhibitors that inhibit oncogenic BRAF without inducing paradoxical pathway activation in cells with mutant RAS might yield improved safety and more durable efficacy.
Alternative RAF inhibitors
Small molecule inhibitors of the signalling kinase RAF are showing promise in the clinic for metastatic melanoma, but have a cavea...

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Full title

RAF inhibitors that evade paradoxical MAPK pathway activation

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Record Identifier

TN_cdi_proquest_miscellaneous_1727436298

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1727436298

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ISSN

0028-0836,1476-4687

E-ISSN

1476-4687

DOI

10.1038/nature14982

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