Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin
Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin
About this item
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Author / Creator
Zenaro, Elena , Pietronigro, Enrica , Bianca, Vittorina Della , Piacentino, Gennj , Marongiu, Laura , Budui, Simona , Turano, Ermanna , Rossi, Barbara , Angiari, Stefano , Dusi, Silvia , Montresor, Alessio , Carlucci, Tommaso , Nanì, Sara , Tosadori, Gabriele , Calciano, Lucia , Catalucci, Daniele , Berton, Giorgio , Bonetti, Bruno and Constantin, Gabriela
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Neutrophils infiltrate the CNS and promote Alzheimer's disease–like pathology and memory loss.
Inflammation is a pathological hallmark of Alzheimer's disease, and innate immune cells have been shown to contribute to disease pathogenesis. In two transgenic models of Alzheimer's disease (5xFAD and 3xTg-AD mice), neutrophils extravasated and were p...
Alternative Titles
Full title
Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin
Authors, Artists and Contributors
Author / Creator
Pietronigro, Enrica
Bianca, Vittorina Della
Piacentino, Gennj
Marongiu, Laura
Budui, Simona
Turano, Ermanna
Rossi, Barbara
Angiari, Stefano
Dusi, Silvia
Montresor, Alessio
Carlucci, Tommaso
Nanì, Sara
Tosadori, Gabriele
Calciano, Lucia
Catalucci, Daniele
Berton, Giorgio
Bonetti, Bruno
Constantin, Gabriela
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1727683218
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1727683218
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3913
