Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
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Author / Creator
Shi, Jianjin , Zhao, Yue , Wang, Kun , Shi, Xuyan , Wang, Yue , Huang, Huanwei , Zhuang, Yinghua , Cai, Tao , Wang, Fengchao and Shao, Feng
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Inflammatory caspases (caspase-1, -4, -5 and -11) are critical for innate defences. Caspase-1 is activated by ligands of various canonical inflammasomes, and caspase-4, -5 and -11 directly recognize bacterial lipopolysaccharide, both of which trigger pyroptosis. Despite the crucial role in immunity and endotoxic shock, the mechanism for pyroptosis...
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Full title
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
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Record Identifier
TN_cdi_proquest_miscellaneous_1728669927
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1728669927
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature15514
