The NF1 Tumor Suppressor Critically Regulates TSC2 and mTOR
The NF1 Tumor Suppressor Critically Regulates TSC2 and mTOR
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Loss-of-function mutations in the NF1 tumor suppressor gene underlie the familial cancer syndrome neurofibromatosis type I (NF1). The NF1-encoded protein, neurofibromin, functions as a Ras-GTPase activating protein (RasGAP). Accordingly, deregulation of Ras is thought to contribute to NF1 development. However, the critical effector pathways involve...
Alternative Titles
Full title
The NF1 Tumor Suppressor Critically Regulates TSC2 and mTOR
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TN_cdi_proquest_miscellaneous_17356696
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_17356696
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0503224102
