A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation
A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
A screen for inhibitors of microglial activation of neuroinflammation identified the compound ICM, which is anti-inflammatory and neuroprotective by targeting HMGB1 and HMGB2, implicating these proteins in a toxic microglial response.
Because of the critical role of neuroinflammation in various neurological diseases, there are continuous efforts...
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Full title
A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation
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TN_cdi_proquest_miscellaneous_1753467019
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1753467019
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1669
