Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9
Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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CRISPR-Cas9 is used for both enrichment and dropout screens of functional enhancers in human cells.
Systematic identification of noncoding regulatory elements has, to date, mainly relied on large-scale reporter assays that do not reproduce endogenous conditions. We present two distinct CRISPR-Cas9 genetic screens to identify and characterize fun...
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Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9
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TN_cdi_proquest_miscellaneous_1768571676
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1768571676
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ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt.3450
