Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Inhibition of polyglutamine-induced protein aggregation could provide treatment options for polyglutamine diseases such as Huntington disease. Here we showed through
in vitro
screening studies that various disaccharides can inhibit polyglutamine-mediated protein aggregation. We also found that various disaccharides reduced polyglutamine aggre...
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Full title
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease
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TN_cdi_proquest_miscellaneous_17700122
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_17700122
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm985
