Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells...
Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Inhibition of ROR-γt impairs T
H
17 responses, but not innate lymphoid cells, and is therapeutically effective in mouse models of intestinal inflammation.
RAR-related orphan receptor-γt (ROR-γt) directs differentiation of proinflammatory T helper 17 (T
H
17) cells and is a potential therapeutic target in chronic autoimmune and inflam...
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Full title
Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells
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TN_cdi_proquest_miscellaneous_1770873343
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1770873343
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4046
