Dynamics inside the cancer cell attractor reveal cell heterogeneity, limits of stability, and escape
Dynamics inside the cancer cell attractor reveal cell heterogeneity, limits of stability, and escape
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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The observed intercellular heterogeneity within a clonal cell population can be mapped as dynamical states clustered around an attractor point in gene expression space, owing to a balance between homeostatic forces and stochastic fluctuations. These dynamics have led to the cancer cell attractor conceptual model, with implications for both carcinog...
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Dynamics inside the cancer cell attractor reveal cell heterogeneity, limits of stability, and escape
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TN_cdi_proquest_miscellaneous_1772146614
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1772146614
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ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.1519210113
