Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models
Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Immunotherapy with antibodies targeting the amyloid-β peptide has yet to show any cognitive benefit in Alzheimer's disease patients in clinical trials.
In vivo
two-photon imaging in mouse models of Alzheimer's disease now reveals that these antibodies do not alleviate neuronal dysfunction and can even worsen it.
Among the most promising ap...
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Full title
Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models
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TN_cdi_proquest_miscellaneous_1773832011
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1773832011
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.4163
