Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies
Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies
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Author / Creator
Rodgers, David T. , Mazagova, Magdalena , Hampton, Eric N. , Cao, Yu , Ramadoss, Nitya S. , Hardy, Ian R. , Schulman, Andrew , Du, Juanjuan , Wang, Feng , Singer, Oded , Ma, Jennifer , Nunez, Vanessa , Shen, Jiayin , Woods, Ashley K. , Wright, Timothy M. , Schultz, Peter G. , Kim, Chan Hyuk and Young, Travis S.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Chimeric antigen receptor T (CAR-T) cell therapy has produced impressive results in clinical trials for B-cell malignancies. However, safety concerns related to the inability to control CAR-T cells once infused into the patient remain a significant challenge. Here we report the engineering of recombinant antibody-based bifunctional switches that co...
Alternative Titles
Full title
Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies
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Record Identifier
TN_cdi_proquest_miscellaneous_1773833239
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1773833239
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1524155113
