Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mech...
Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies
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England: Nature Publishing Group
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English
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England: Nature Publishing Group
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In 1990, more than 10 years after the discovery that the low molecular weight GTPase Ras is a major contributor to human cancer, farnesylation, a lipid posttranslational modification required for the cancer-causing activity of Ras, emerged as a major target for the development of novel anticancer agents. However, it took only 5 years from 1993, whe...
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Full title
Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies
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TN_cdi_proquest_miscellaneous_17843114
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_17843114
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/sj.onc.1204146
