Metabolic Regulation of Brain Aβ by Neprilysin
Metabolic Regulation of Brain Aβ by Neprilysin
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Publisher
Washington, DC: American Society for the Advancement of Science
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Language
English
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Publisher
Washington, DC: American Society for the Advancement of Science
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Contents
Amyloid β peptide (Aβ), the pathogenic agent of Alzheimer's disease (AD), is a physiological metabolite in the brain. We examined the role of neprilysin, a candidate Aβ-degrading peptidase, in the metabolism using neprilysin gene-disrupted mice. Neprilysin deficiency resulted in defects both in the degradation of exogenously administered Aβ and in...
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Full title
Metabolic Regulation of Brain Aβ by Neprilysin
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TN_cdi_proquest_miscellaneous_17880539
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_17880539
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1059946
