Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patie...
Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial
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Author / Creator
Nywening, Timothy M, MD , Wang-Gillam, Andrea, MD , Sanford, Dominic E, MD , Belt, Brian A, MA , Panni, Roheena Z, MD , Cusworth, Brian M, BA , Toriola, Adetunji T, MD , Nieman, Rebecca K, MS , Worley, Lori A, BS , Yano, Motoyo, MD , Fowler, Kathryn J, MD , Lockhart, A Craig, MD , Suresh, Rama, MD , Tan, Benjamin R, MD , Lim, Kian-Huat, MD , Fields, Ryan C, MD , Strasberg, Steven M, Prof , Hawkins, William G, Prof , DeNardo, David G, PhD , Goedegebuure, S Peter, PhD and Linehan, David C, Dr Prof
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publication information
Publisher
England: Elsevier Ltd
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More information
Scope and Contents
Contents
Summary Background In pancreatic ductal adenocarcinoma, the CCL2–CCR2 chemokine axis is used to recruit tumour-associated macrophages for construction of an immunosuppressive tumour microenvironment. This pathway has prognostic implications in pancreatic cancer, and blockade of CCR2 restores anti-tumour immunity in preclinical models. We aimed to e...
Alternative Titles
Full title
Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial
Authors, Artists and Contributors
Author / Creator
Wang-Gillam, Andrea, MD
Sanford, Dominic E, MD
Belt, Brian A, MA
Panni, Roheena Z, MD
Cusworth, Brian M, BA
Toriola, Adetunji T, MD
Nieman, Rebecca K, MS
Worley, Lori A, BS
Yano, Motoyo, MD
Fowler, Kathryn J, MD
Lockhart, A Craig, MD
Suresh, Rama, MD
Tan, Benjamin R, MD
Lim, Kian-Huat, MD
Fields, Ryan C, MD
Strasberg, Steven M, Prof
Hawkins, William G, Prof
DeNardo, David G, PhD
Goedegebuure, S Peter, PhD
Linehan, David C, Dr Prof
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1797543084
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1797543084
Other Identifiers
ISSN
1470-2045
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(16)00078-4
