OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of met...
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin
About this item
Full title
Author / Creator
Chen, Ligong , Shu, Yan , Liang, Xiaomin , Chen, Eugene C. , Yee, Sook Wah , Zur, Arik A. , Li, Shuanglian , Xu, Lu , Keshari, Kayvan R. , Lin, Michael J. , Chien, Huan-Chieh , Zhang, Youcai , Morrissey, Kari M. , Liu, Jason , Ostrem, Jonathan , Younger, Noah S. , Kurhanewicz, John , Shokat, Keven M. , Ashrafi, Kaveh and Giacomini, Kathleen M.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Organic cation transporter 1, OCT1 (SLC22A1), is the major hepatic uptake transporter for metformin, the most prescribed antidiabetic drug. However, its endogenous role is poorly understood. Here we show that similar to metformin treatment, loss of Oct1 caused an increase in the ratio of AMP to ATP, activated the energy sensor AMP-activated kinase...
Alternative Titles
Full title
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin
Authors, Artists and Contributors
Author / Creator
Shu, Yan
Liang, Xiaomin
Chen, Eugene C.
Yee, Sook Wah
Zur, Arik A.
Li, Shuanglian
Xu, Lu
Keshari, Kayvan R.
Lin, Michael J.
Chien, Huan-Chieh
Zhang, Youcai
Morrissey, Kari M.
Liu, Jason
Ostrem, Jonathan
Younger, Noah S.
Kurhanewicz, John
Shokat, Keven M.
Ashrafi, Kaveh
Giacomini, Kathleen M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1803108036
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1803108036
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1314939111
