Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: R...
Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: Relevance to trypanosome lysis
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Significance African trypanosomes are parasites that can cause African sleeping sickness in humans. Host defense against some of these is provided by the human serum factor apolipoprotein L-1 (APOL1), which causes swelling and lysis of susceptible trypanosomes. Lysis follows uptake of APOL1 into acidic parasite endosomes and is thought to involve i...
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Full title
Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: Relevance to trypanosome lysis
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TN_cdi_proquest_miscellaneous_1803126319
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1803126319
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1421953112
