Functional genomics identifies therapeutic targets for MYC-driven cancer
Functional genomics identifies therapeutic targets for MYC-driven cancer
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
MYC oncogene family members are broadly implicated in human cancers, yet are considered “undruggable” as they encode transcription factors. MYC also carries out essential functions in proliferative tissues, suggesting that its inhibition could cause severe side effects. We elected to identify synthetic lethal interactions with c-MYC overexpression...
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Full title
Functional genomics identifies therapeutic targets for MYC-driven cancer
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Record Identifier
TN_cdi_proquest_miscellaneous_1803158762
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1803158762
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1121119109
